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Topotecan

Synonyms

SourcesNames Used
CCLE, GRAY, FIMMTopotecan
CTRPv2topotecan
PharmacoGx Topotecan

External IDs

DatabaseIdentifier
Smiles: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)[NH+]=C5C=CC(=C(C5=C4)CN(C)C)O)O.[Cl-]
Inchikey: DGHHQBMTXTWTJV-BQAIUKQQSA-N
Pubchem: 11972519

Annotated Targets

TOP1MT, TOP1

Cell lines tested with Topotecan

952 cell lines have been tested with this compound, using data from 4 dataset(s).
MDA-MB-468 breast CCLE, GRAY, FIMM, CTRPv27
SK-BR-3 breast CCLE, GRAY, FIMM, CTRPv26
MDA-MB-453 breast CCLE, GRAY, FIMM, CTRPv26
HCC1395 breast CCLE, GRAY, CTRPv26
BT-474 breast CCLE, GRAY, FIMM, CTRPv26
MDA-MB-361 breast GRAY, CTRPv25
MDA-MB-231 breast GRAY, FIMM, CTRPv25
HCC2185 breast GRAY5
HCC1419 breast GRAY, CTRPv25
ZR-75-1 breast CCLE, GRAY, FIMM, CTRPv25
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Top molecular features associated with response to Topotecan


Feature TypeStandardized
Nominal ANOVA
mRNA SLFN11 CTRPv2 AAC 0.37 2e-29
mRNA SLFN11 CCLE AAC 0.42 9e-23
mRNA ELAVL1 CTRPv2 AAC 0.28 8e-16
mRNA KLHL23 CTRPv2 AAC 0.28 2e-15
mRNA SAFB CTRPv2 AAC 0.27 3e-14
mRNA KHDRBS1 CTRPv2 AAC 0.25 5e-14
mRNA FAM117B CTRPv2 AAC 0.24 3e-13
mRNA TMPO CTRPv2 AAC 0.24 3e-13
mRNA CENPV CTRPv2 AAC 0.25 4e-13
mRNA LMNB1 CTRPv2 AAC 0.25 4e-13
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