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tipifarnib

Synonyms

SourcesNames Used
CTRPv2tipifarnib-P2, tipifarnib-P1
PharmacoGx tipifarnib

External IDs

DatabaseIdentifier
Smiles: Cn1cncc1[C@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Pubchem: 159324

Annotated Targets

FNTA, FNTB

Cell lines tested with tipifarnib

860 cell lines have been tested with this compound, using data from 1 dataset(s).
A549 lung CTRPv26
IGROV-1 ovary CTRPv24
P3HR-1 haematopoietic and lymphoid tissue CTRPv24
CAL-51 breast CTRPv24
NCI-H460 lung CTRPv24
NCI-H1299 lung CTRPv24
SUIT-2 pancreas CTRPv24
A375 skin CTRPv24
OAW-28 ovary CTRPv23
HeLa cervix CTRPv23
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Top molecular features associated with response to tipifarnib


Feature TypeStandardized
Nominal ANOVA
mRNA FAM117B CTRPv2 AAC 0.24 2e-13
mRNA DOT1L CTRPv2 AAC 0.26 5e-11
mRNA ZNF397 CTRPv2 AAC 0.21 2e-10
mRNA RP11-1212A22.4 CTRPv2 AAC 0.21 3e-10
mRNA ARHGDIG CTRPv2 AAC 0.2 8e-10
mRNA NPIPA7 CTRPv2 AAC 0.2 9e-10
mRNA BCOR CTRPv2 AAC 0.21 1e-09
mRNA SLC35E2 CTRPv2 AAC 0.2 1e-09
mRNA NPIPA5 CTRPv2 AAC 0.2 1e-09
mRNA SHPRH CTRPv2 AAC 0.21 2e-09
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