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TGX221

Synonyms

SourcesNames Used
GDSC1000TGX221
CTRPv2TGX-221
PharmacoGx TGX221

External IDs

DatabaseIdentifier
Smiles: CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4
Inchikey: CPRAGQJXBLMUEL-UHFFFAOYSA-N
Pubchem: 9907093

Annotated Targets

PIK3CB, PIK3CD

Cell lines tested with TGX221

1068 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung CTRPv23
NCI-H1299 lung GDSC1000, CTRPv23
NCI-H1869 lung GDSC1000, CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
P3HR-1 haematopoietic and lymphoid tissue GDSC1000, CTRPv23
DU-145 prostate CTRPv22
AsPC-1 pancreas CTRPv22
CCF-STTG1 central nervous system CTRPv22
OAW-28 ovary CTRPv22
HeLa cervix CTRPv22
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Top molecular features associated with response to TGX221


Feature TypeStandardized
Nominal ANOVA
mRNA C5orf46 GDSC1000 AAC 0.38 6e-14
mRNA ZC3H12D CTRPv2 AAC 0.26 4e-10
mRNA LOXL2 GDSC1000 AAC 0.4 7e-10
mRNA FGF7 GDSC1000 AAC 0.26 2e-08
mRNA HEG1 GDSC1000 AAC 0.32 4e-08
mRNA FCRL1 CTRPv2 AAC 0.2 4e-08
mRNA PLEKHA2 CTRPv2 AAC 0.22 5e-08
mRNA FCRL2 CTRPv2 AAC 0.2 9e-08
mRNA IGFBP3 GDSC1000 AAC 0.3 9e-08
mRNA C1S GDSC1000 AAC 0.31 1e-07
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