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Sorafenib

Synonyms

SourcesNames Used
CCLE, GDSC1000, GRAY, FIMMSorafenib
CTRPv2sorafenib
PharmacoGx Sorafenib

External IDs

DatabaseIdentifier
Smiles: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Inchikey: MLDQJTXFUGDVEO-UHFFFAOYSA-N
Pubchem: 216239

Annotated Targets

BRAF, KIT, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, PDGFRB, RAF1, RET

Cell lines tested with Sorafenib

1150 cell lines have been tested with this compound, using data from 5 dataset(s).
Hs-578-T breast CCLE, GRAY, FIMM, CTRPv26
BT-474 breast CCLE, GDSC1000, GRAY, FIMM, CTRPv26
MDA-MB-231 breast GRAY, FIMM, CTRPv25
HCC1428 breast GRAY, CTRPv25
ZR-75-1 breast CCLE, GRAY, FIMM, CTRPv25
SK-BR-3 breast CCLE, GRAY, FIMM, CTRPv25
MDA-MB-453 breast CCLE, GRAY, FIMM, CTRPv25
MDA-MB-157 breast CCLE, GRAY, CTRPv25
MCF7 breast CCLE, GRAY, FIMM, CTRPv25
BT-549 breast CCLE, GRAY, FIMM, CTRPv25
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Top molecular features associated with response to Sorafenib


Feature TypeStandardized
Nominal ANOVA
mRNA SERPINI2 CCLE AAC 0.52 9e-33
mRNA TIFAB CCLE AAC 0.45 2e-25
mRNA PPP1R27 CCLE AAC 0.42 7e-22
mRNA KCNE5 CCLE AAC 0.42 1e-21
mRNA AZU1 CCLE AAC 0.41 9e-21
mRNA MS4A6A CCLE AAC 0.42 4e-20
mRNA SEL1L2 CCLE AAC 0.4 5e-20
mRNA SLC26A8 CCLE AAC 0.4 5e-20
mRNA RNASE2 CCLE AAC 0.4 3e-19
mRNA CCL23 CCLE AAC 0.4 7e-19
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