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ruxolitinib

Synonyms

SourcesNames Used
GDSC1000Ruxolitinib
CTRPv2ruxolitinib
PharmacoGx ruxolitinib

External IDs

DatabaseIdentifier
Smiles: N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Pubchem: 25126798

Annotated Targets

JAK2, JAK1, JAK3, TYK2

Cell lines tested with ruxolitinib

1285 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung CTRPv23
NCI-H1869 lung GDSC1000, CTRPv23
SUIT-2 pancreas GDSC1000, CTRPv23
P3HR-1 haematopoietic and lymphoid tissue GDSC1000, CTRPv23
DU-145 prostate GDSC1000, CTRPv23
NCI-H1299 lung GDSC1000, CTRPv23
OAW-28 ovary GDSC1000, CTRPv23
NCI-H460 lung GDSC1000, CTRPv23
NCI-H520 lung GDSC1000, CTRPv23
CAL-51 breast GDSC1000, CTRPv23
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Top molecular features associated with response to ruxolitinib


Feature TypeStandardized
Nominal ANOVA
mRNA ANKRD27 CTRPv2 AAC 0.43 1e-35
mRNA MYL4 CTRPv2 AAC 0.38 3e-31
mRNA CSF2RB CTRPv2 AAC 0.39 2e-30
mRNA RP11-153I24.5 CTRPv2 AAC 0.36 2e-28
mRNA LDB1 CTRPv2 AAC 0.37 2e-26
mRNA XK CTRPv2 AAC 0.36 8e-26
mRNA SOS1 CTRPv2 AAC 0.35 4e-25
mRNA C6orf25 CTRPv2 AAC 0.34 6e-25
mRNA GAB3 CTRPv2 AAC 0.39 8e-25
mRNA ITGA2B CTRPv2 AAC 0.34 1e-24
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