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RDEA119

Synonyms

SourcesNames Used
GDSC1000RDEA119
FIMMRefametinib
PharmacoGx RDEA119

External IDs

DatabaseIdentifier
Smiles: COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
Inchikey: RDSACQWTXKSHJT-NSHDSACASA-N
Pubchem: 44182295

Cell lines tested with RDEA119

1003 cell lines have been tested with this compound, using data from 2 dataset(s).
PC-3 prostate GDSC1000, FIMM3
BT-549 breast GDSC1000, FIMM3
MV-4-11 haematopoietic and lymphoid tissue GDSC1000, FIMM3
NOMO-1 haematopoietic and lymphoid tissue GDSC1000, FIMM3
OCI-AML5 haematopoietic and lymphoid tissue GDSC1000, FIMM3
IGROV-1 ovary GDSC1000, FIMM3
DU-4475 breast GDSC1000, FIMM3
MDA-MB-453 breast GDSC1000, FIMM3
ML-2 haematopoietic and lymphoid tissue GDSC1000, FIMM3
CAL-85-1 breast GDSC1000, FIMM3
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Top molecular features associated with response to RDEA119


Feature TypeStandardized
Nominal ANOVA
mRNA TIMP1 GDSC1000 AAC 0.33 9e-25
mRNA SPRY2 GDSC1000 AAC 0.33 3e-23
mRNA CTSB GDSC1000 AAC 0.34 6e-22
mRNA GSN GDSC1000 AAC 0.34 8e-21
mRNA ACTN1 GDSC1000 AAC 0.35 4e-20
mRNA S100A11 GDSC1000 AAC 0.32 4e-20
mRNA CD44 GDSC1000 AAC 0.3 6e-20
mRNA DDX60L GDSC1000 AAC 0.29 6e-20
mRNA LMNA GDSC1000 AAC 0.36 2e-19
mRNA FAM129B GDSC1000 AAC 0.42 4e-19
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