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RAF265

Synonyms

SourcesNames Used
CCLE, FIMM, CTRPv2RAF265
PharmacoGx RAF265

External IDs

DatabaseIdentifier
Smiles: CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
Inchikey: YABJJWZLRMPFSI-UHFFFAOYSA-N
Pubchem: 11656518

Annotated Targets

BRAF, KDR

Cell lines tested with RAF265

830 cell lines have been tested with this compound, using data from 3 dataset(s).
A549 lung CCLE, CTRPv24
ZR-75-1 breast CCLE, FIMM, CTRPv23
T47D breast CCLE, FIMM, CTRPv23
SUIT-2 pancreas CCLE, CTRPv23
SK-OV-3 ovary CCLE, FIMM, CTRPv23
SK-BR-3 breast CCLE, FIMM, CTRPv23
SIG-M5 haematopoietic and lymphoid tissue CCLE, FIMM, CTRPv23
P3HR-1 haematopoietic and lymphoid tissue CCLE, CTRPv23
OVCAR-8 ovary CCLE, FIMM, CTRPv23
OV-90 ovary CCLE, FIMM, CTRPv23
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Top molecular features associated with response to RAF265


Feature TypeStandardized
Nominal ANOVA
mRNA LINGO1 CTRPv2 AAC 0.28 3e-11
mRNA AAED1 CCLE AAC 0.3 1e-08
mRNA SH2B2 CCLE AAC -0.31 3e-08
mRNA KCNN3 CCLE AAC -0.28 7e-08
mRNA MAOB CTRPv2 AAC 0.22 8e-08
mRNA MARVELD1 CCLE AAC 0.31 9e-08
mRNA SFXN3 CCLE AAC 0.3 2e-07
mRNA CMTM3 CCLE AAC 0.27 2e-07
mRNA B4GALT6 CTRPv2 AAC 0.22 3e-07
mRNA ESRRG CTRPv2 AAC 0.21 3e-07
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