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PLX4720

Synonyms

SourcesNames Used
CCLE, GDSC1000PLX4720
CTRPv2PLX-4720
PharmacoGx PLX4720

External IDs

DatabaseIdentifier
Smiles: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
Inchikey: YZDJQTHVDDOVHR-UHFFFAOYSA-N
Pubchem: 24180719

Annotated Targets

BRAF, KDR

Cell lines tested with PLX4720

1320 cell lines have been tested with this compound, using data from 3 dataset(s).
A549 lung CCLE, GDSC1000, CTRPv26
NCI-H520 lung CCLE, GDSC1000, CTRPv25
NCI-H460 lung CCLE, GDSC1000, CTRPv25
NCI-H1869 lung CCLE, GDSC1000, CTRPv25
LOXIMVI haematopoietic and lymphoid tissue CCLE, GDSC1000, CTRPv25
DU-145 prostate CCLE, GDSC1000, CTRPv25
AsPC-1 pancreas CCLE, GDSC1000, CTRPv25
A375 skin CCLE, GDSC1000, CTRPv25
OAW-28 ovary GDSC1000, CTRPv24
IGROV-1 ovary GDSC1000, CTRPv24
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Top molecular features associated with response to PLX4720


Feature TypeStandardized
Nominal ANOVA
mRNA RXRG CTRPv2 AAC 0.38 6e-22
mRNA SPRY4 CTRPv2 AAC 0.35 2e-21
mRNA MMP8 GDSC1000 AAC 0.35 3e-20
mRNA MIA-RAB4B CTRPv2 AAC 0.37 8e-20
mRNA CTHRC1 CTRPv2 AAC 0.33 1e-19
mRNA NFATC2 CTRPv2 AAC 0.37 3e-19
mRNA INPP5F CTRPv2 AAC 0.41 5e-19
mRNA MYL10 CTRPv2 AAC 0.3 2e-18
mRNA ITGB3 CTRPv2 AAC 0.35 4e-18
mRNA MIA CTRPv2 AAC 0.35 4e-18
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