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AZ628

Synonyms

SourcesNames Used
GDSC1000AZ628
PharmacoGx AZ628

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C
Inchikey: ZGBGPEDJXCYQPH-UHFFFAOYSA-N
Pubchem: 11676786

Annotated Targets

BRAF, RAF1

Cell lines tested with AZ628

429 cell lines have been tested with this compound, using data from 1 dataset(s).
L-363 haematopoietic and lymphoid tissue GDSC10001
SU-DHL-6 haematopoietic and lymphoid tissue GDSC10001
JVM-3 haematopoietic and lymphoid tissue GDSC10001
L-428 haematopoietic and lymphoid tissue GDSC10001
ACN autonomic ganglia GDSC10001
D-542MG central nervous system GDSC10001
BB49-HNC upper aerodigestive tract GDSC10001
TE-8 oesophagus GDSC10001
BE-13 haematopoietic and lymphoid tissue GDSC10001
KALS-1 central nervous system GDSC10001
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Top molecular features associated with response to AZ628


Feature TypeStandardized
Nominal ANOVA
mRNA DUSP6 GDSC1000 AAC 0.38 4e-15
mRNA SPRY4 GDSC1000 AAC 0.38 5e-13
mRNA RAB39B GDSC1000 AAC -0.37 2e-12
mRNA ETV5 GDSC1000 AAC 0.34 1e-11
mRNA LTBR GDSC1000 AAC 0.39 3e-11
mRNA OAF GDSC1000 AAC 0.34 5e-11
mRNA ST3GAL4 GDSC1000 AAC 0.34 2e-10
mRNA TYRP1 GDSC1000 AAC 0.32 7e-10
mRNA KIAA0930 GDSC1000 AAC 0.29 1e-09
mRNA CLEC11A GDSC1000 AAC 0.3 1e-09
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