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GDC-0941

Synonyms

SourcesNames Used
GDSC1000GDC0941
gCSIgdc0941
FIMMPictilisib
CTRPv2GDC-0941
PharmacoGx GDC-0941

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
Inchikey: LHNIIDJUOCFXAP-UHFFFAOYSA-N
Pubchem: 17755052

Annotated Targets

PIK3CA, PIK3CB, PIK3CD, PIK3CG

Cell lines tested with GDC-0941

1304 cell lines have been tested with this compound, using data from 4 dataset(s).
IGROV-1 ovary GDSC1000, gCSI, FIMM, CTRPv26
A549 lung GDSC1000, gCSI, CTRPv26
CAL-51 breast GDSC1000, gCSI, FIMM, CTRPv26
SK-OV-3 ovary GDSC1000, gCSI, FIMM, CTRPv25
PC-3 prostate GDSC1000, gCSI, FIMM, CTRPv25
BT-549 breast GDSC1000, gCSI, FIMM, CTRPv25
RPMI-8226 haematopoietic and lymphoid tissue GDSC1000, gCSI, FIMM, CTRPv25
MDA-MB-453 breast GDSC1000, gCSI, FIMM, CTRPv25
NCI-H1869 lung GDSC1000, gCSI, CTRPv25
CCF-STTG1 central nervous system GDSC1000, gCSI, CTRPv25
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Top molecular features associated with response to GDC-0941


Feature TypeStandardized
Nominal ANOVA
mRNA NCKAP1 GDSC1000 AAC -0.45 3e-12
mRNA FOXO1 CTRPv2 AAC 0.22 1e-09
mRNA GGA2 CTRPv2 AAC 0.23 1e-08
mRNA BMF CTRPv2 AAC 0.2 2e-08
mRNA CYP2A6 CTRPv2 AAC 0.2 3e-08
mRNA TTC7A GDSC1000 AAC 0.21 6e-08
mRNA TAT CTRPv2 AAC 0.19 7e-08
mRNA APBB1IP GDSC1000 AAC 0.26 1e-07
mRNA GSTA3 CTRPv2 AAC 0.19 1e-07
mRNA CXorf21 GDSC1000 AAC 0.24 1e-07
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