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alvocidib

Synonyms

SourcesNames Used
CTRPv2alvocidib
PharmacoGx alvocidib

External IDs

DatabaseIdentifier
Smiles: CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Pubchem: 5287969

Annotated Targets

CDK4, CDK2, CDK6, CDK1, CDK5, CDK7, CDK8, CDK9, EGFR, PYGM

Cell lines tested with alvocidib

440 cell lines have been tested with this compound, using data from 1 dataset(s).
DU-145 prostate CTRPv22
AsPC-1 pancreas CTRPv22
NCI-H1869 lung CTRPv22
CCF-STTG1 central nervous system CTRPv22
YAMATO N/A CTRPv21
TTC709 N/A CTRPv21
TM87-16 N/A CTRPv21
SYO1 N/A CTRPv21
SW982 soft tissue CTRPv21
BT16 N/A CTRPv21
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Top molecular features associated with response to alvocidib


Feature TypeStandardized
Nominal ANOVA
mRNA GAS6 CTRPv2 AAC -0.33 4e-12
mRNA BCL2L1 CTRPv2 AAC -0.35 5e-11
mRNA PAMR1 CTRPv2 AAC -0.3 5e-10
mRNA FAM114A1 CTRPv2 AAC -0.35 7e-10
mRNA KRTAP1-5 CTRPv2 AAC -0.3 1e-09
mRNA GREM1 CTRPv2 AAC -0.29 2e-09
mRNA TRIM8 CTRPv2 AAC -0.3 2e-09
mRNA LRP1 CTRPv2 AAC -0.3 7e-09
mRNA HSPB6 CTRPv2 AAC -0.28 9e-09
mRNA MYOF CTRPv2 AAC -0.31 1e-08
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