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alisertib

Synonyms

SourcesNames Used
CTRPv2alisertib
PharmacoGx alisertib

External IDs

DatabaseIdentifier
Smiles: COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O
Pubchem: 24771867

Annotated Targets

AURKA, AURKB

Cell lines tested with alisertib

838 cell lines have been tested with this compound, using data from 1 dataset(s).
2004 N/A CTRPv21
22RV1 prostate CTRPv21
23132-87 stomach CTRPv21
253J urinary tract CTRPv21
253J-BV urinary tract CTRPv21
42-MG-BA central nervous system CTRPv21
5637 urinary tract CTRPv21
639-V urinary tract CTRPv21
647-V urinary tract CTRPv21
697 haematopoietic and lymphoid tissue CTRPv21
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Tissues tested with alisertib

24 tissues have been tested with this compound, using data from 1 dataset(s).
central nervous systemCTRPv247
breastCTRPv237
stomachCTRPv232
urinary tractCTRPv224
thyroidCTRPv210
haematopoietic and lymphoid tissueCTRPv2153
autonomic gangliaCTRPv215
liverCTRPv222
kidneyCTRPv220
pleuraCTRPv28
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Top molecular features associated with response to alisertib


Feature TypeStandardized
Nominal ANOVA
mRNA HNRNPA1 CTRPv2 AAC 0.32 6e-19
mRNA CBX2 CTRPv2 AAC 0.3 1e-18
mRNA MBTD1 CTRPv2 AAC 0.3 9e-16
mRNA ZBED4 CTRPv2 AAC 0.29 9e-16
mRNA KHDRBS1 CTRPv2 AAC 0.26 7e-15
mRNA MEX3A CTRPv2 AAC 0.3 8e-15
mRNA LMNB1 CTRPv2 AAC 0.26 3e-14
mRNA ARHGAP19 CTRPv2 AAC 0.29 4e-14
mRNA ARHGAP19-SLIT1 CTRPv2 AAC 0.28 1e-13
mRNA FAM117B CTRPv2 AAC 0.24 1e-13
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