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AEW541

Synonyms

SourcesNames Used
CCLEAEW541
PharmacoGx AEW541

External IDs

DatabaseIdentifier
Smiles: C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
Inchikey: AECDBHGVIIRMOI-UHFFFAOYSA-N
Pubchem: 11476171

Annotated Targets

IGF1R

Cell lines tested with AEW541

503 cell lines have been tested with this compound, using data from 1 dataset(s).
ZR-75-30 breast CCLE1
ZR-75-1 breast CCLE1
YKG-1 central nervous system CCLE1
WM-983B skin CCLE1
WM-88 skin CCLE1
WM-793 skin CCLE1
WM-266-4 skin CCLE1
WM1799 skin CCLE1
WM-115 skin CCLE1
VMRC-RCZ kidney CCLE1
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Top molecular features associated with response to AEW541


Feature TypeStandardized
Nominal ANOVA
mRNA AMPD1 CCLE AAC 0.31 1e-11
mRNA IGF1R CCLE AAC 0.32 1e-11
mRNA TP53INP1 CCLE AAC 0.29 7e-10
mRNA GPRC5D CCLE AAC 0.28 7e-10
mRNA DEK CCLE AAC -0.27 1e-09
mRNA NLRC3 CCLE AAC -0.42 6e-09
mRNA PTPRC CCLE AAC -0.42 2e-08
mRNA SASH3 CCLE AAC -0.4 2e-08
mRNA SWT1 CCLE AAC 0.26 2e-08
mRNA C1orf56 CCLE AAC 0.26 3e-08
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