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UHNBreast

Acronym

University Health Network (UHN) Breast Cancer (BC) Screen

Description

Molecular profiling and pharmacological screening of a selection of 84 breast cancer cell lines undertaken at the Princess Margaret Cancer Centre to identify cancer treatment targets and drug biomarkers.

Resources

Data Website

RNA-seq data

Functional genetic screen data

Publications

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance; Cell 2016

Data types

Data Type Assay/Platform Raw Processed
Pharmacological Sulforhodamine B colorimetric Yes AUC, IC50
mRNA expression Illumina HiSeq 2000 RNAseq Yes FPKM
DNA Copy Number Illumina Human Omni-Quad No logR
Protein Expression RPPA No MicroVigene expression intensity

PharmacoGx

PharmacoSet object for: UHNBreast

All compounds tested in UHNBreast

4 compounds have been tested in this dataset.
AZD6244Erlotinib
lapatinibpaclitaxel
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