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GDSC1000

Acronym

Genomics of Drug Sensitivity in Cancer (GDSC)

Description

The Genomics of Drug Sensitivity in Cancer ​(GDSC) ​Project is part of a Wellcome Trust funded collaboration between The Cancer Genome Project at the Wellcome Trust Sanger Institute (UK) and the Center for Molecular Therapeutics,​ Massachusetts General Hospital Cancer Center (USA). As part of this collaboration,​ the GDSC group is screening >1000 genetically characterised human cancer cell lines with a wide range of anti-cancer therapeutics. These compounds include cytotoxic chemotherapeutics as well as targeted therapeutics from commercial sources, academic collaborators,​ and from the biotech and pharmaceutical industries. The sensitivity patterns of the cell lines are correlated with extensive ​(epi)genomic and expression data to identify genetic features that are predictive of sensitivity. This large collection of cell lines aims at capturing much of the genomic heterogeneity that underlies human cancer, and which appears to play a critical role in determining the variable response of patients to treatment with specific agents.

As part of this collaboration, the GDSC group is screening >1000 genetically characterised human cancer cell lines with a wide range of anti-cancer therapeutics. These compounds include cytotoxic chemotherapeutics as well as targeted therapeutics from commercial sources, academic collaborators, and from the biotech and pharmaceutical industries. The sensitivity patterns of the cell lines are correlated with extensive genomic and expression data to identify genetic features that are predictive of sensitivity. This large collection of cell lines aims at capturing much of the genomic heterogeneity that underlies human cancer, and which appears to play a critical role in determining the variable response of patients to treatment with specific agents.

Resources

GDSC website

Microarray gene expression data

Publication

Systematic identification of genomic markers of drug sensitivity in cancer cells, Nature 2012

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells, Nucleic Acids Research 2013

Data types

Data Type Assay/Platform Raw Processed
Pharmacological Syto60 Yes AUC, IC50
mRNA Expression Affymetrix HG-U133A Yes RMA
DNA Copy Number Affymetrix SNP 6.0 Yes PICNIC
DNA Mutation Sanger No CSV
DNA Methylation Illumina array 450K Yes GenomeStudio

PharmacoGx

PharmacoSet object for: GDSC1000

All cell lines tested in GDSC1000

1075 cell lines have been tested in this dataset.
201T22RV1
23132-8742-MG-BA
451Lu5637
639-V647-V
697769-P
786-08-MG-BA
8305C8505C
A101DA172
A204A2058
A253A2780
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