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CCLE

Acronym

Broad-Novartis Cancer Cell Line Encyclopedia (CCLE)

Description

The Cancer Cell Line Encyclopedia (CCLE) project is a collaboration between the Broad Institute, the Novartis Institutes for Biomedical Research, and its Genomics Institute of the Novartis Research Foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models, to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer patient stratification. The CCLE provides public access to genomic data as well as analysis and visualization for about 1000 cell lines.

Resources

CCLE website

RNA-seq on NCI Genomic Data Commons

Publication

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity, Nature 2012

Data type

Data Type Assay/Platform Raw Processed
Pharmacological CellTiter Glo Yes AUC, IC50
mRNA Expression Affymetrix HG-U133PLUS2 Yes BrainArray, RMA
Illumina RNA-seq Yes No
DNA Copy Number Affymetrix SNP 6.0 Yes Birdseed, Normalized log2 ratios
DNA Mutation OncoMap No MAF
Hybrid Capture Yes MAF

PharmacoGx

PharmacoSet object for: CCLE

All cell lines tested in CCLE

504 cell lines have been tested in this dataset.
1321N122RV1
42-MG-BA5637
639-V697
769-P786-0
8-MG-BA8305C
8505CA172
A204A2058
A253A2780
A375A549
A673ACHN
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